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<!--Generated by Squarespace V5 Site Server v5.13.594-SNAPSHOT-1 (http://www.squarespace.com) on Tue, 09 Jun 2026 06:14:39 GMT--><feed xmlns="http://www.w3.org/2005/Atom" xmlns:dc="http://purl.org/dc/elements/1.1/"><title>Journal</title><subtitle>Journal</subtitle><id>http://macastat.com/journal/</id><link rel="alternate" type="application/xhtml+xml" href="http://macastat.com/journal/"/><link rel="self" type="application/atom+xml" href="http://macastat.com/journal/atom.xml"/><updated>2023-11-24T22:16:09Z</updated><generator uri="http://www.squarespace.com/" version="Squarespace V5 Site Server v5.13.594-SNAPSHOT-1 (http://www.squarespace.com)">Squarespace</generator><entry><title>Passing from one epoch to the next</title><id>http://macastat.com/journal/2023/11/24/passing-from-one-epoch-to-the-next.html</id><link rel="alternate" type="text/html" href="http://macastat.com/journal/2023/11/24/passing-from-one-epoch-to-the-next.html"/><author><name>macastat</name></author><published>2023-11-24T21:38:05Z</published><updated>2023-11-24T21:38:05Z</updated><content type="html" xml:lang="en-US"><![CDATA[<div id="_mcePaste">What will the future bring. A thought experiment beginning 6000 years ago and concluding 6000 years from now. &nbsp;Based on the Book by Peter Zeihan,&nbsp;<span style="caret-color: #4d5156; color: #4d5156; font-family: arial, sans-serif; font-size: 14px;">The End of the World Is Just the Beginning. &nbsp;</span></div>
<div><span style="caret-color: #4d5156; color: #4d5156; font-family: arial, sans-serif; font-size: 14px;"><br /></span></div>
<div id="_mcePaste"></div>
<div id="_mcePaste">He demonstrates that our decades long period of hyper globalization is all but over. Our species has sprinted over the last thousands of years from a time where, without brute daily consumption, the baby dies! There was no bandwidth for regeneration. This has carried us forward until today. No judgment. So much of what we have accomplished demonstrates the near limitless potential of our species. &nbsp;But obviously, perpetual consumption without regeneration is not something that can last.</div>
<div></div>
<div>And in some ways, hyper globalization, may naturally lead to hyper&mdash; Localism!</div>
<div></div>
<div>Especially around fundamentals of daily thriving, like food, water, shelter, energy, community. &nbsp;America has virtually every requirement for perpetual self-sufficiency, again based on your analysis. &nbsp;</div>
<div></div>
<div>That said, ug, in the near term, we are certainly facing at best a worldwide depression, as the pillars of hyper globalization begin to more clearly fail. We may lose millions upon millions to famine. China decivilizes. The emotional response to this will be overwhelming, but also temporary.</div>
<div></div>
<div>&nbsp;Then, given the regeneration of the United States into a juggernaut of anti-fragility &mdash; and hopefully also coupled with a sense of regeneration of the entire species into more giving and regeneratively minded decentralized groups - we get a harmony between the broader thriving North Americans and thousands of local bio regions and so on. A reestablishment of balance in everything we do. Including a balance between individual prosperity and security and that of the community. Less affected by inflation, centralized currency, government etc by the nature of being small and local. &nbsp;</div>
<div></div>
<div>Nothing is assured but it&rsquo;s not impossible. We could one day achieve this, through collective manifestation. &nbsp;Not saying there won&rsquo;t be suffering, loss, death, murder. Just won&rsquo;t be mass murder. &nbsp;</div>
<div></div>
<div>Our reality is malleable, no matter how you look at it.</div>
<div></div>
<div>So let us band together, combined the wisdom of our grandmothers with our collective brain power and determine the state of our species after we emerge from this epic epoch portal.</div>]]></content></entry><entry><title>Born to Binge Lifestyle</title><id>http://macastat.com/journal/2022/9/5/born-to-binge-lifestyle.html</id><link rel="alternate" type="text/html" href="http://macastat.com/journal/2022/9/5/born-to-binge-lifestyle.html"/><author><name>macastat</name></author><published>2022-09-05T16:35:34Z</published><updated>2022-09-05T16:35:34Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p>&nbsp;</p>
<div id="_mcePaste">EM and born to binge!</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Here is one easy solution to consider. Pharmaceutical free, painless, and most crucially something you can do the rest of your life. &nbsp;&nbsp;</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">***Anecdote alert anecdotal alert anecdotal alert***</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">I wanted to share my personal experience with losing that 10% of flab. A struggle for the last three decades, solved! &nbsp;</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">A true panacea???:&nbsp;</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Born to Binge Diet</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">&nbsp;(aka &lsquo;it&rsquo;s not fasting diet&rsquo;). &nbsp;</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">TL/DR : &nbsp;Focus on the positive. &nbsp;Eat well and without limits, do so over eight hours daily. Minimal calories for remaining 16. &nbsp;That is, this is not about &ldquo;fasting&ldquo; it&rsquo;s about Binging (so to speak) &nbsp;</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">With myself as a test subject this is the only sustainable lasting strategy I&rsquo;ve ever adopted to rid that ridiculous unsightly blubber around my middle. &nbsp;</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">&mdash;&mdash;-</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Further details if you&rsquo;re interested.</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Caveats first. My feelings are this likely works well in males. Still not sure if this is wise for females but would love input if anyone is trying this.</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Other hacks I&rsquo;m employing simultaneously which by themselves did not produce the same affects but are probably cofactors:</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">-All the low-lying fruit, with a goal of minimizing basal cortisol level and maximizing mitochondrial fitness. &nbsp;No drinkable carbs, mindful of amount of simple carb inputed, living food probiotics daily, daily aerobics, don&rsquo;t use exercise as a weight loss strategy, exercise in whatever manner causes the least psychological stress. &nbsp;Must must must have a stress reduction, mindfulness, meditation, prayer , breathing practices to decrease those basal cortisol levels. &nbsp;Sauna and cold plunge daily. &nbsp;View bright light for at least a few minutes every morning to facilitate necessary late morning cortisol spike. &nbsp; Pro tip, use something like the Reveri app and do self hypnosis regularly. &nbsp;Similarly consider finding a good therapist. Elucidate and then manage all the soul trauma we carry with us. Maximize intimate time with partner (multiple benefits!). &nbsp;</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Background. This strategy was inspired by Mickey Musumeci. &nbsp;He is a Brazilian jujitsu multiple world champion. During an interview on the Joe Rogan podcast he shared his pasta diet. Basically making his own pizza and pasta, eating as much as he likes and then fasting the rest of the day. He shared this was the most stress-free means to make weight. It&rsquo;s a great interview if you&rsquo;re interested. Actually pretty inspiring. &nbsp;</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">He is almost exactly my same ideal weight, about 140 pounds. &nbsp;So though despite this seemingly violating laws of thermaldynamics as mentioned in other comments, for him and again anecdotally for me it absolutely does work. &nbsp;Perhaps where dissipating dark energy or something lol.</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Adaptively it does at least have some face value. Our great great great great great grandfather&rsquo;s and mothers, whom by definition impossibly survived to create us, probably did some form of this. And the farther back you go, the more likely this is true if you think about it.</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Test subject, me. 53 year old emergency physician no medical problems or meds - no dx but have had borderline elevated blood pressures. &nbsp;Compact frame, 5&lsquo;8&ldquo;. &nbsp;Borderline hypertension.Half Filipino and has Eastern European. &nbsp;When I was at Peak during athletic years, say 18 years old, I weighed about 130 pounds. During times in the inner-city trauma center, divorce, no mindfulness practices etc. etc., my peak weight was almost 160 pounds. My hemoglobin A1c crept up to about 6.4. Father has DMII.</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Physically, all of that 30 pounds was around my middle, and likely in my visceral organs. So I have the dreaded SkinnyFat. Compact frame with flab in the middle.&nbsp;</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Have casually tried almost every reasonable diet out there from prolong fasting, intermittent fasting / time restricted, Paleo, low-carb. Almost everything does actually work. For a while. Like everyone in the world who diets, would never stick. &nbsp;It was seemingly overnight, exactly back to where I was. Sometimes even slightly worse.</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Exercise. I hate to work out. It stresses me out. So I don&rsquo;t do it. Instead, I just change the language a bit and it&rsquo;s just part of a lifestyle. I try to stand as much as possible. A hike regularly. I have the fortune of living on a forest property, so there&rsquo;s always physical things that have to happen. It&rsquo;s like a constant fun workout all the time. I installed pull up handles coming down from my cabin loft. I use these two descend and do approximately 20 pull ups, at least every other day. I try to sprint from point-to-point, because I like sprinting and it&rsquo;s a little bonus workout of lower extremities. &nbsp;I do one random pose supramaximal Whole body contraction during exhalation, every other day.</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">During activity goal of keeping heart rate below the aerobic anaerobic threshold, for me at my age it&rsquo;s about 130. Hack here, as long as you can breathe through your nose, you&rsquo;re still aerobic!</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">In the mindfulness realm, I use the app mentioned above every day. I deploy an &ldquo;air aroma&rdquo; breathing practice. This is analogous to box breathing or 4 x 4 breathing. My hack is to sample the scent of the air while slowly inhaling, do a little stutterstep physiologic sigh like a baby. &nbsp;Strive for total lung capacity while doing so. Smelling the air distracts my crazy mind for a second, and clears out some of the gunk. This than leads to a form of self hypnosis, where I connect with what I think of as a divine soul. The self soul melding leads to healing and inspiration.</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">And as to the diet. So like Mikey I love pizza and pasta. &nbsp;It&rsquo;s one of those things that he alludes to that I seemingly could eat without limits.</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">So specifically I eat as much as I want over a 6 to 8 hour period. &nbsp;This is always good food, whole-grain pasta&rsquo;s and pizza, try to make or buy made from scratch. Local ingredients, from my Farmer friends. An outstanding dessert even if hi carb. &nbsp;I kind of allow myself to gorge actually. It is so pleasurable that not eating for the remaining 16 hours is almost like foreplay lol. It really does result in a net positive. Again by focusing on the positive, the binge and treating the negative, the fast as part of the binge, I feel like my overall will to continue is maximized and the psychic stress is minimized. This is easily something I could do for the rest of my life and intend to.</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">And because I do Emergency Medicine and the time frames are sometimes less consistent. That is, I focus less on the time of the day and more on the intervals. So if I end up eating a little bit later into the day, say last calories at 10 PM, I simply don&rsquo;t start my next eight hour binge until 2 PM the next day. &nbsp;If I want to start eating an earlier time, I accept the occasional shorter fast period period. &nbsp;My average time is roughly noon to 8 PM. On Night Shift I typically don&rsquo;t eat anything all day and then in the first few hours of my shift I start my binge. &nbsp;I know this may sound crazy, but since doing this, I&rsquo;m actually quite alert by morning still. Not sure if it&rsquo;s the diet but this is the only time in decades I&rsquo;ve had this pleasurable wakefulness all the way to 8 AM.</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Results. I feel like my ideal weight, not being too skinny, not having blubber is 140 pounds. I&rsquo;ve been employing this practice for about six weeks now - and counting. After the first few weeks, I step on the scale and I swear been around 139.9 pounds every single day, no matter how much I&rsquo;ve binged the day before. I feel healthy, energetic and calm. Heart rate averaging around 59. Blood pressures normal. A1c normal. &nbsp;I have a little adipose around my middle but overall I am overjoyed with my physique. &nbsp;I feel more vital than I did when I was 18. &nbsp;</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Anyway it&rsquo;s just my thoughts on this. Love to hear if anyone else again is using this strategy??</div>
<div id="_mcePaste"></div>
<div id="_mcePaste"></div>
<div id="_mcePaste"></div>
<div id="_mcePaste"></div>
<div id="_mcePaste"></div>
<p>EM and born to binge!<br />Here is one easy solution to consider. Pharmaceutical free, painless, and most crucially something you can do the rest of your life. &nbsp;&nbsp;<br />***Anecdote alert anecdotal alert anecdotal alert***<br />I wanted to share my personal experience with losing that 10% of flab. A struggle for the last three decades, solved! &nbsp;<br />A true panacea???:&nbsp;<br />Born to Binge Diet<br />&nbsp;(aka &lsquo;it&rsquo;s not fasting diet&rsquo;). &nbsp;<br />TL/DR : &nbsp;Focus on the positive. &nbsp;Eat well and without limits, do so over eight hours daily. Minimal calories for remaining 16. &nbsp;That is, this is not about &ldquo;fasting&ldquo; it&rsquo;s about Binging (so to speak) &nbsp;<br />With myself as a test subject this is the only sustainable lasting strategy I&rsquo;ve ever adopted to rid that ridiculous unsightly blubber around my middle. &nbsp;<br />&mdash;&mdash;-<br />Further details if you&rsquo;re interested.<br />Caveats first. My feelings are this likely works well in males. Still not sure if this is wise for females but would love input if anyone is trying this.<br />Other hacks I&rsquo;m employing simultaneously which by themselves did not produce the same affects but are probably cofactors:<br />-All the low-lying fruit, with a goal of minimizing basal cortisol level and maximizing mitochondrial fitness. &nbsp;No drinkable carbs, mindful of amount of simple carb inputed, living food probiotics daily, daily aerobics, don&rsquo;t use exercise as a weight loss strategy, exercise in whatever manner causes the least psychological stress. &nbsp;Must must must have a stress reduction, mindfulness, meditation, prayer , breathing practices to decrease those basal cortisol levels. &nbsp;Sauna and cold plunge daily. &nbsp;View bright light for at least a few minutes every morning to facilitate necessary late morning cortisol spike. &nbsp; Pro tip, use something like the Reveri app and do self hypnosis regularly. &nbsp;Similarly consider finding a good therapist. Elucidate and then manage all the soul trauma we carry with us. Maximize intimate time with partner (multiple benefits!). &nbsp;<br />Background. This strategy was inspired by Mickey Musumeci. &nbsp;He is a Brazilian jujitsu multiple world champion. During an interview on the Joe Rogan podcast he shared his pasta diet. Basically making his own pizza and pasta, eating as much as he likes and then fasting the rest of the day. He shared this was the most stress-free means to make weight. It&rsquo;s a great interview if you&rsquo;re interested. Actually pretty inspiring. &nbsp;<br />He is almost exactly my same ideal weight, about 140 pounds. &nbsp;So though despite this seemingly violating laws of thermaldynamics as mentioned in other comments, for him and again anecdotally for me it absolutely does work. &nbsp;Perhaps where dissipating dark energy or something lol.<br />Adaptively it does at least have some face value. Our great great great great great grandfather&rsquo;s and mothers, whom by definition impossibly survived to create us, probably did some form of this. And the farther back you go, the more likely this is true if you think about it.<br />Test subject, me. 53 year old emergency physician no medical problems or meds - no dx but have had borderline elevated blood pressures. &nbsp;Compact frame, 5&lsquo;8&ldquo;. &nbsp;Borderline hypertension.Half Filipino and has Eastern European. &nbsp;When I was at Peak during athletic years, say 18 years old, I weighed about 130 pounds. During times in the inner-city trauma center, divorce, no mindfulness practices etc. etc., my peak weight was almost 160 pounds. My hemoglobin A1c crept up to about 6.4. Father has DMII.<br />Physically, all of that 30 pounds was around my middle, and likely in my visceral organs. So I have the dreaded SkinnyFat. Compact frame with flab in the middle.&nbsp;<br />Have casually tried almost every reasonable diet out there from prolong fasting, intermittent fasting / time restricted, Paleo, low-carb. Almost everything does actually work. For a while. Like everyone in the world who diets, would never stick. &nbsp;It was seemingly overnight, exactly back to where I was. Sometimes even slightly worse.<br />Exercise. I hate to work out. It stresses me out. So I don&rsquo;t do it. Instead, I just change the language a bit and it&rsquo;s just part of a lifestyle. I try to stand as much as possible. A hike regularly. I have the fortune of living on a forest property, so there&rsquo;s always physical things that have to happen. It&rsquo;s like a constant fun workout all the time. I installed pull up handles coming down from my cabin loft. I use these two descend and do approximately 20 pull ups, at least every other day. I try to sprint from point-to-point, because I like sprinting and it&rsquo;s a little bonus workout of lower extremities. &nbsp;I do one random pose supramaximal Whole body contraction during exhalation, every other day.<br />During activity goal of keeping heart rate below the aerobic anaerobic threshold, for me at my age it&rsquo;s about 130. Hack here, as long as you can breathe through your nose, you&rsquo;re still aerobic!<br />In the mindfulness realm, I use the app mentioned above every day. I deploy an &ldquo;air aroma&rdquo; breathing practice. This is analogous to box breathing or 4 x 4 breathing. My hack is to sample the scent of the air while slowly inhaling, do a little stutterstep physiologic sigh like a baby. &nbsp;Strive for total lung capacity while doing so. Smelling the air distracts my crazy mind for a second, and clears out some of the gunk. This than leads to a form of self hypnosis, where I connect with what I think of as a divine soul. The self soul melding leads to healing and inspiration.<br />And as to the diet. So like Mikey I love pizza and pasta. &nbsp;It&rsquo;s one of those things that he alludes to that I seemingly could eat without limits.<br />So specifically I eat as much as I want over a 6 to 8 hour period. &nbsp;This is always good food, whole-grain pasta&rsquo;s and pizza, try to make or buy made from scratch. Local ingredients, from my Farmer friends. An outstanding dessert even if hi carb. &nbsp;I kind of allow myself to gorge actually. It is so pleasurable that not eating for the remaining 16 hours is almost like foreplay lol. It really does result in a net positive. Again by focusing on the positive, the binge and treating the negative, the fast as part of the binge, I feel like my overall will to continue is maximized and the psychic stress is minimized. This is easily something I could do for the rest of my life and intend to.<br />And because I do Emergency Medicine and the time frames are sometimes less consistent. That is, I focus less on the time of the day and more on the intervals. So if I end up eating a little bit later into the day, say last calories at 10 PM, I simply don&rsquo;t start my next eight hour binge until 2 PM the next day. &nbsp;If I want to start eating an earlier time, I accept the occasional shorter fast period period. &nbsp;My average time is roughly noon to 8 PM. On Night Shift I typically don&rsquo;t eat anything all day and then in the first few hours of my shift I start my binge. &nbsp;I know this may sound crazy, but since doing this, I&rsquo;m actually quite alert by morning still. Not sure if it&rsquo;s the diet but this is the only time in decades I&rsquo;ve had this pleasurable wakefulness all the way to 8 AM.<br />Results. I feel like my ideal weight, not being too skinny, not having blubber is 140 pounds. I&rsquo;ve been employing this practice for about six weeks now - and counting. After the first few weeks, I step on the scale and I swear been around 139.9 pounds every single day, no matter how much I&rsquo;ve binged the day before. I feel healthy, energetic and calm. Heart rate averaging around 59. Blood pressures normal. A1c normal. &nbsp;I have a little adipose around my middle but overall I am overjoyed with my physique. &nbsp;I feel more vital than I did when I was 18. &nbsp;<br />Anyway it&rsquo;s just my thoughts on this. Love to hear if anyone else again is using this strategy??<br /><br /></p>
<p>&nbsp;</p>]]></content></entry><entry><title>Perhaps the simplest life hack, optimize how I communicate</title><id>http://macastat.com/journal/2021/10/30/perhaps-the-simplest-life-hack-optimize-how-i-communicate.html</id><link rel="alternate" type="text/html" href="http://macastat.com/journal/2021/10/30/perhaps-the-simplest-life-hack-optimize-how-i-communicate.html"/><author><name>macastat</name></author><published>2021-10-30T16:35:36Z</published><updated>2021-10-30T16:35:36Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p>One of my favorite podcasts, EmCrit, Recently said that one of the most impactful books ever read is Dr. Rosenberg's, nonviolent communication.&nbsp;</p>
<p>To me it boils down to this. I often find myself in the trap of being stuck in my own head when I communicate. This over time probably lowers the chance of having truly effective conversations. &nbsp;I mean, what's the point of communication if it's not effective communication. In other words only effective communication is just <span style="text-decoration: underline;">communication</span> lol &nbsp;</p>
<p>&nbsp;</p>
<div id="_mcePaste">In my humble interpretation it comes down to this&hellip;&nbsp;</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">What I&rsquo;m calling&nbsp;</div>
<div></div>
<div id="_mcePaste"></div>
<div id="_mcePaste">ComCom</div>
<div></div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Which refers to effective communication using compassion for yourself AND for the person your are conversing with.&nbsp;</div>
<div></div>
<div id="_mcePaste"></div>
<div id="_mcePaste">The reason to even think about this is given the numerous times a day we are communicating with people for a variety of reasons and degrees of urgency. What if we all set a goal to make 100% of those As mutually effective as possible.</div>
<div></div>
<div id="_mcePaste"></div>
<div id="_mcePaste">The reason, Everybody lives their best life. There is no Shangri-La but there is some theoretical best possible state.</div>
<div></div>
<div id="_mcePaste"></div>
<div id="_mcePaste">ComComm has two simple Objectives</div>
<div id="_mcePaste"></div>
<div id="_mcePaste">&nbsp;</div>
<div>win AND win. &nbsp;</div>
<div></div>
<div id="_mcePaste"></div>
<div id="_mcePaste">Listen&nbsp;</div>
<div id="_mcePaste">Deeply&nbsp;</div>
<div id="_mcePaste">Within.&nbsp;</div>
<div>&nbsp;</div>
<div id="_mcePaste"></div>
<div id="_mcePaste"></div>
<div id="_mcePaste"></div>
<div></div>
<div></div>
<div></div>
<p>Details to follow &hellip;.</p>
<p>&nbsp;</p>]]></content></entry><entry><title>COVID &amp; the Cellular Signal Corps.</title><category term="CoVid"/><category term="Emergency Medicine"/><category term="coronavirus"/><category term="covid-19"/><id>http://macastat.com/journal/2020/4/28/covid-the-cellular-signal-corps.html</id><link rel="alternate" type="text/html" href="http://macastat.com/journal/2020/4/28/covid-the-cellular-signal-corps.html"/><author><name>macastat</name></author><published>2020-04-28T14:57:10Z</published><updated>2020-04-28T14:57:10Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p><span id="docs-internal-guid-08e094ec-7fff-a0c1-1b4d-a5e61e70d38a"> </span></p>
<h2><span>COVID &amp; the Cellular Signal Corps.&nbsp;</span></h2>
<p dir="ltr"><span><em>&nbsp;&nbsp;Tony Macasaet, MD, FACEP</em></span></p>
<p>&nbsp;</p>
<p dir="ltr"><strong><span>Hypothesis</span><span>: inspired by the heroic, frontline efforts of emergency physicians like Dr. Caleb Hernandez, COVID-19 </span><span>may</span><span>, in part, be a leukotriene/bradykinin mediated angioedema-like state, especially affecting the most distal parts of the airways and alveoli. Net effect of viral infection leading to increased vascular permeability, upper and lower airway and tissue edema, bronchospasm, excess mucin production, dysregulated inflammation, thrombosis and eventually epithelial hyperplasia and fibrosis. Fortunately like angioedema, it may be rapidly reversible if treated early with epinephrine, antimuscarinics and leukotriene blockade. Dramatic anecdotal results are consistent with a positive response, suggesting these concepts are worthy of further study.&nbsp;&nbsp;</span></strong></p>
<p><br /><br /></p>
<h3><span>Discussion</span></h3>
<p dir="ltr"><span>Medications that MIGHT have benefit and my commentary on mechanisms:</span></p>
<ol>
<li dir="ltr">
<p dir="ltr"><span>Montelukast po. See review below. Use may lead to less bronchoconstriction, mucus, airway edema, inflammation, and fibrosis</span></p>
</li>
<li dir="ltr">
<p dir="ltr"><span>Epinephrine Intramuscular (if inadequate infusion pumps).&nbsp; Vasoconstriction in increased contractility of course. Increases respiratory rate, bronchodilation, decreased vascular permeability and improved tissue and airway edema. This includes improved upper airway edema if present. Shifts Oxygen&ndash;hemoglobin dissociation curve, promoting better tissue oxygenation&nbsp;</span></p>
</li>
<li dir="ltr">
<p dir="ltr"><span>ADH / Vasopressin IM.&nbsp; Arteriolar vasoconstriction and free water reabsorption.&nbsp;</span></p>
</li>
<li dir="ltr">
<p dir="ltr"><span>Atropine IM. &nbsp; Muscarinic antagonist - causing decreased respiratory secretions.</span></p>
</li>
<li dir="ltr">
<p dir="ltr"><span>Systemic&nbsp; anticoagulation</span></p>
</li>
</ol>
<p>&nbsp;</p>
<p dir="ltr"><span>This cocktail in severe, failing COVID-19 MAY provide:</span></p>
<ol>
<li dir="ltr">
<p dir="ltr"><span>Decreased upper AND lower airway edema/bronchoconstriction, improving WOB and oxygenation&nbsp;</span></p>
</li>
<li dir="ltr">
<p dir="ltr"><span>Decreased alveolar edema/flooding, loss of surfactant, failure of oxygen absorption etc etc&nbsp;</span></p>
</li>
<li dir="ltr">
<p dir="ltr"><span>Decreased respiratory secretions</span></p>
</li>
<li dir="ltr">
<p dir="ltr"><span>Improved overall perfusion and tissue oxygenation.&nbsp;</span></p>
</li>
</ol>
<p>&nbsp;</p>
<p dir="ltr"><span><strong>Strictly my own summary and discussion. &nbsp;</strong></span></p>
<p dir="ltr"><span>Montelukast - high affinity leukotriene receptor blocker. Evidence it blocks bradykinin too.&nbsp;</span></p>
<p>I had to recall that leukotrienes are signaling molecules produced in immune cells. Made from Arachidonic acid (AA). AA is of course the building block of our beloved phospholipid bilayer and part of numerous signaling molecules. AA itself may have a role in the inflammatory cascade.</p>
<p>Leukotrienes released from white cells bind to leukotrienes receptors on the cell wall of respiratory epithelial cells, airway smooth muscle cells, airway macrophages and other pro-inflammatory cells. &nbsp;</p>
<p dir="ltr"><span>With binding, leukotrienes trigger cellular signaling, leading to effects such as:</span></p>
<ul>
<li dir="ltr">
<p dir="ltr"><span>Increased release of </span><span>histamine</span><span> and prostaglandins.</span></p>
</li>
</ul>
<ul>
<li dir="ltr">
<p dir="ltr"><span>Heightened bronchiolar smooth muscle tone, with small airway </span><span>bronchoconstriction</span><span>.</span></p>
</li>
<li dir="ltr">
<p dir="ltr"><span>Copious mucus production, increased vascular permeability, edema</span></p>
</li>
<li dir="ltr">
<p dir="ltr"><span>Hyper-responsiveness to bronchoconstriction (some </span><span>resistance to B-agonists</span><span>??)</span></p>
</li>
<li dir="ltr">
<p dir="ltr"><span>further </span><span>pro-inflammatory cell recruitment.&nbsp;&nbsp;</span></p>
</li>
<li dir="ltr">
<p dir="ltr"><span>Not to mention smooth muscle proliferation, collagen deposition, and </span><span>fibrosis</span><span>.</span></p>
</li>
<li dir="ltr">
<p dir="ltr"><span>Increased mucin secretion by goblet cells and respiratory epithelial cell hypertrophy.&nbsp; </span><span>So, snot cells on steroids!!</span></p>
</li>
<li dir="ltr">
<p dir="ltr"><span>Increased permeability of the blood brain barrier. </span><span>Dysregulation of blood-brain barrier.</span></p>
</li>
</ul>
<p dir="ltr"><span>Thus, there is at least biological plausibility the above cocktail of somewhat every day medications, in many a crashcart and medicine cabinet has a net benefit. Hypothesis generating.</span></p>
<p>&nbsp;</p>
<p dir="ltr"><span>Taking it just a little further, SARS-Cov-2 infects respiratory epithelial cells, gaining access via the ACE2 receptor on the cell wall. The receptor and the virus are involuted into the cell. Because of decreased ACE2 receptor activity, bradykinin increases (normally metabolized by ACE2). This then may lead to increased vascular permeability, bronchospasm, edema etc. etc.&nbsp; Again, there is research suggesting montelukast blocks bradykinin receptor activity similar to leukotrienes.&nbsp;</span></p>
<p>So, perhaps in the end the key will be blocking the effects of bradykinin and or leukotrienes, which may be released as part of COVID-19. That is Montelukast, and good old epinephrine, atropine, and vasopressin.&nbsp;</p>
<p dir="ltr"><span>Along these lines, other medications to ponder might include: Icatibant, TXA, H1 and H2 blockers, aminophylline, and Cromolyn among others.&nbsp;</span></p>
<p dir="ltr"><span><br /></span></p>
<h3><span>Bottom Line Speculation</span></h3>
<p>Mechanistically COVID-19 may be behaving in part somewhat akin to an angioedema-like process + micro pulmonary/systemic thromboembolism. Leading to catastrophic end-organ hypoxia.&nbsp; Antagonizing these effects may reverse the seemingly unstoppable death spiral of COVID-19.&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>]]></content></entry><entry><title>Driftless Thrive Podcast, ep. 1</title><category term="driftless"/><category term="film"/><category term="film"/><category term="movie"/><category term="podcast"/><category term="thrive"/><id>http://macastat.com/journal/2020/4/19/driftless-thrive-podcast-ep-1.html</id><link rel="alternate" type="text/html" href="http://macastat.com/journal/2020/4/19/driftless-thrive-podcast-ep-1.html"/><author><name>macastat</name></author><published>2020-04-19T13:15:00Z</published><updated>2020-04-19T13:15:00Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p><span>Inaugural Driftless Thrive 20/20 podcast conference.</span><br /><br /><span>Hope, flow, joy and solutions.</span><br /><br /><span>Will schedule others - watch for invites!</span></p>
<p>&nbsp;</p>
<p><span><iframe src="https://player.vimeo.com/video/409517251" width="640" height="360" frameborder="0" allow="autoplay; fullscreen" allowfullscreen></iframe></span></p>
<p>&nbsp;</p>]]></content></entry><entry><title>Covidication</title><category term="2020"/><category term="CoVid"/><category term="Covidication"/><category term="Viroqua"/><category term="df"/><id>http://macastat.com/journal/2020/3/9/covidication.html</id><link rel="alternate" type="text/html" href="http://macastat.com/journal/2020/3/9/covidication.html"/><author><name>macastat</name></author><published>2020-03-09T20:29:52Z</published><updated>2020-03-09T20:29:52Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p>How to thrive on the post-Covid Earth.</p>
<p>&nbsp;</p>
<p>In the future, what will we value most?</p>
<p>&nbsp;</p>
<p>Prolly something like:</p>
<p>1) Shelter.</p>
<p>So, let us manifest earthen permanent homes crafted of materials nearby.... and master the tech to reproduce them indefinitely&nbsp;</p>
<p>2) Sustenance.</p>
<p>&nbsp;Matrix of interconnected families, each producing sustenance. Hive capitalism. &nbsp;Trade between neighbors. Micro-grid energy-coops.&nbsp;</p>
<p>3) Society.&nbsp;</p>
<p>Foster an alliance of neighbors. Agree we may disagree. Cooperate, collaborate, honor each family and individual.&nbsp;</p>
<p>For, in a way, our tribe must thrive to survive. &nbsp;</p>
<p>4) Soul. &nbsp;Follow bliss. &nbsp;Allow for your best self. &nbsp;Assemble and gather healers, artisans, creators, leaders, sages. &nbsp;Welcome the likeminded.&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>&nbsp;</p>]]></content></entry><entry><title>Some featured short film projects</title><id>http://macastat.com/journal/2020/3/4/some-featured-short-film-projects.html</id><link rel="alternate" type="text/html" href="http://macastat.com/journal/2020/3/4/some-featured-short-film-projects.html"/><author><name>macastat</name></author><published>2020-03-04T21:26:00Z</published><updated>2020-03-04T21:26:00Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p>______</p>
<p><strong>F E A T U R E D&nbsp;&nbsp; F I L M S</strong></p>
<p>&nbsp;</p>
<p><strong>Music Video Short: Work &amp; Wisdom</strong></p>
<p><strong><br /></strong></p>
<p>&nbsp;<iframe src="http://player.vimeo.com/video/64270218" width="700" height="300" frameborder="0" webkitAllowFullScreen mozallowfullscreen allowFullScreen></iframe></p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>Music Video: Elephant Love (version 1)</p>
<p>Original works by the band Soul Music</p>
<p><iframe src="http://player.vimeo.com/video/63299619" width="700" height="300" frameborder="0" webkitAllowFullScreen mozallowfullscreen allowFullScreen></iframe></p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<div></div>]]></content></entry><entry><title>Hive Capitalism</title><category term="bliss"/><category term="capitalism"/><category term="coop"/><category term="cooperative"/><category term="hive"/><category term="solution to worlds problems"/><id>http://macastat.com/journal/2019/6/7/hive-capitalism.html</id><link rel="alternate" type="text/html" href="http://macastat.com/journal/2019/6/7/hive-capitalism.html"/><author><name>macastat</name></author><published>2019-06-07T20:37:46Z</published><updated>2019-06-07T20:37:46Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p><span>The 10,000 year run of the cult of private wealth accumulation has mostly failed us. Mother Earth is kicking back and for many whatever comes, will be disruptive and unpleasant. The aforementioned threat is real. However, must all suffer and what precisely shall we do about all this?</span>&nbsp;</p>
<p><span>Parking capital in the coffers of an elite few, putting morality aside, is simply unacceptably inefficient. &nbsp;</span></p>
<p><span>Moreover the interconnected digital world, has grotesquely distorted our natural tendency to cooperate into a destructive abomination. Instead of nurturing individuality our binary avatars have become soldiers of in-group bias, concentrating us into likeminded groups. Comrades to a few and enemies to all else. Including ourselves</span>&nbsp;</p>
<p><span>Thus we have been indoctrinated into a death cult of the amassing of individual wealth at all costs, of Competition over Collaboration. We perceive humanity as groups not humans, self as group not soul.</span>&nbsp;</p>
<p><span>The solution is not about redistribution of wealth or other impossible measures - it&rsquo;s about what shall we choose to do with the wealth we are about to create!</span>&nbsp;</p>
<p><span>Those holding the capital cards are perhaps 1 billion times more wealthy. What could possibly overcome this magnitude of disparity?&nbsp; It is the power of the mind and true self, repentant, re-directed, revived. Specifically, it is the power of each interconnected revitalized soul, cooperating together, each following their bliss mission, generating capital, the surplus of which is shared equally.&nbsp; And with each added member, the power grows exponentially, soon eclipsing our folly and forging a new way.&nbsp;</span></p>
<p><span>Let us form a scaffolding that allows participants to sculpt a web of bliss energy that joyfully tangles us together. Thus manifesting a village where each citizen rides the currents of Devine flow, interwoven. For it is this flow state, that sustains our souls.&nbsp; The garden of Eden before shame.</span></p>
<p><span>To repeat, one person actualized in Bliss flow added to another exponentially grows the bliss energy.&nbsp;</span></p>
<p><span>This bliss flow may seem intangible and hypothetical but we are incorporating something acutely real. Bliss flow is joyful tasks that benefit our culture, infused with the love energy of Mother Earth and the others who have gathered here (and likely generating profit).&nbsp; All built on a shared wisdom ensuring sustainability despite our egos and flaws. &nbsp;</span></p>
<p><span>Certainly in Viroqua and the Driftless we already participate in a spontaneously formed primordial cooperative society.&nbsp; Now is the moment and place to formally organize into hive capitalism. Mission Driven Cooperative Companies Owned by Shareholders. One share equals one vote. No hierarchy; there is no guru upon a throne to disappoint us. In fact, each member is a guru. And when it is our time to lead, it is accomplished with service and selflessness.</span></p>
<p><span>&nbsp;</span>The vision - create wealth generating cooperative ventures which fill cooperative coffers. Then supply capital for additional worthy projects. And of course, celebrate and appreciate.&nbsp;</p>
<p>Our mission: to leave a lasting positive effect.</p>
<p><span>The timeline, 70 generations of our descendants, living within a society, we are poised to revise and optimize.&nbsp;</span></p>
<p><span>Thus, I propose to you, hive capitalism.&nbsp; Now is the place and the time to energize our tribal mind (and our tribal banking). &nbsp;</span></p>
<p><span>&nbsp;</span></p>
<p><span>&nbsp;</span></p>]]></content></entry><entry><title>Fox Cave Trailcam Series</title><category term="Viroqua"/><category term="driftless"/><category term="fox"/><category term="red fox"/><category term="trailcam"/><id>http://macastat.com/journal/2019/6/1/fox-cave-trailcam-series.html</id><link rel="alternate" type="text/html" href="http://macastat.com/journal/2019/6/1/fox-cave-trailcam-series.html"/><author><name>macastat</name></author><published>2019-06-01T20:59:00Z</published><updated>2019-06-01T20:59:00Z</updated><content type="html" xml:lang="en-US"><![CDATA[<p>&nbsp;</p>
<div id="_mcePaste">This family resides in a mossy cliffside cave, 80 feet above a box canyon and the South Fork of the Bad Axe Creek - on my cabin property outside of Viroqua, Driftless. &nbsp;They've granted permission to film their comings and goings. &nbsp;I shall post captures often and we can observe the kits' development. &nbsp;Can you guess how many children she has?</div>
<div><em style="font-size: 50%;"><span><br /></span></em></div>
<div id="_mcePaste"></div>
<div id="_mcePaste"><em style="font-size: 50%;"><span>*WARNING - video series may depict semi-violent sibling grappling, dismembered prey, and scary fox kit eating predators.</span></em></div>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>Episode 1</p>
<p><iframe width="560" height="315" src="https://www.youtube.com/embed/_5P2l0kNaYQ" frameborder="0" allow="accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe>&nbsp;</p>
<p>&nbsp;</p>
<p>Episode 2</p>
<p>&nbsp;</p>
<div style="padding: 56.25% 0 0 0; position: relative;"><iframe src="https://player.vimeo.com/video/93906572" style="position:absolute;top:0;left:0;width:100%;height:100%;" frameborder="0" allow="autoplay; fullscreen" allowfullscreen></iframe></div>
<p><script src="https://player.vimeo.com/api/player.js"></script></p>
<p>&nbsp;</p>
<p>&nbsp;</p>
<p>Episode 3, finale</p>
<p>&nbsp;</p>
<div style="padding: 56.25% 0 0 0; position: relative;"><iframe src="https://player.vimeo.com/video/94559331" style="position:absolute;top:0;left:0;width:100%;height:100%;" frameborder="0" allow="autoplay; fullscreen" allowfullscreen></iframe></div>
<p><script src="https://player.vimeo.com/api/player.js"></script></p>
<p>&nbsp;</p>
<p>&nbsp;</p>]]></content></entry><entry><title>No House at All</title><category term="Viroqua"/><category term="driftless"/><category term="exploration"/><category term="haunted"/><id>http://macastat.com/journal/2013/12/28/no-house-at-all.html</id><link rel="alternate" type="text/html" href="http://macastat.com/journal/2013/12/28/no-house-at-all.html"/><author><name>macastat</name></author><published>2013-12-28T21:09:35Z</published><updated>2013-12-28T21:09:35Z</updated><content type="html" xml:lang="en-US"><![CDATA[<div>I cannot attest to the authenticity of any of the suppositions and claims made &nbsp;herein however I will share my understanding of the background behind this photograph.&nbsp;</div>
<div></div>
<div><span class="full-image-block ssNonEditable"><span><img src="http://macastat.com/storage/1504380_10152103024997661_583798471_o.jpg?__SQUARESPACE_CACHEVERSION=1388265952200" alt="" /></span></span></div>
<div></div>
<div><!--?xml version="1.0" encoding="UTF-8" standalone="no"?-->
<div></div>
<div></div>
<div>This is an assumed haunted house, moments east of Viroqua, Vernon County Wisconsin USA. I can't tell you the exact address as the street sign off the gravel road off the gravel road off the gravel road off of a gravel road was either not there or very unclear.</div>
<div></div>
<div></div>
<div>Having explored countless of these in my lifetime, when I encountered this one - which I had never somehow seen before - I could not resist peeking around inside.</div>
<div></div>
<div></div>
<div>Coincidentally, I was listening to a radio program about exploring abandoned places. I liked the phrase they used, take nothing and leave only footprints.&nbsp; It gave me comfort, implying I would likely leave intact.</div>
<div></div>
<div></div>
<div>The abode was only a few feet from the road, so I presumed it would be ramshackled and pillaged - converted into yet another mundane, boring place, by numerous prior like-minded explorers. Nothing very interesting here I'm sure.</div>
<div></div>
<div></div>
<div>However, I was shocked, almost nauseous, when I enter.&nbsp; As I think of it now, I'm struck by a chill equal to the one afflicting me as I walked in.</div>
<div></div>
<div></div>
<div>&nbsp;Other than the dilapidated state of the structure itself, it was as if people were still there. Or more accurately, it was as if they were there one second, and then gone the next.&nbsp; A couple strides past the threshold I quickly turn assuming someone was running up behind me.&nbsp; Of course, there's no one.</div>
<div></div>
<div></div>
<div>The attire of a middle aged couple are still hanging in the wardrobe and thrown across a still made bed.&nbsp; A lumpy fold in the sheets, a sleeping body, simulated.</div>
<div></div>
<div></div>
<div>A cute little workshop, with nails nuts and bolts, neatly organized into dusty masonry jars.</div>
<div></div>
<div></div>
<div>And then the kitchen, where the photograph was taken.&nbsp; Flatware left exactly where it was last placed. A weird greasy stain leaves an outline around each piece. A bowl still seemingly filled with supper set at the head of the table. The National Geographic from 1983, turned over waiting patiently to be picked up and completed.</div>
<div></div>
<div></div>
<div>And the clock on the wall.&nbsp; The damn clock. Stopped intriguingly at 7:20. What was it.&nbsp; Batteries finally died.&nbsp; Or, don't know. It disturbes me to look at it.</div>
<div></div>
<div></div>
<div>There's a steak knife. Stainded with mystery meat.&nbsp; A saucer with amber residue on the floor.&nbsp; Was there a poor pet here too now vanished with its master?</div>
<div></div>
<div></div>
<div>Compelled by slaughtered expectations, I command a seat at the table. Not out of disrespect but remembrance.&nbsp; Maybe it will gift me some form of understanding what occurred here at 7:20, 1983.</div>
<div></div>
</div>
<div></div>
<div></div>
<div><span class="full-image-block ssNonEditable"><span><img src="http://macastat.com/storage/1486108_10152121312722661_869180684_o.jpg?__SQUARESPACE_CACHEVERSION=1388265992035" alt="" /></span></span></div>
<div><br />
<div>
<div>With a startle, I launch upward.&nbsp; An intense sudden grumble, completely out of place in this forsaken emptiness.&nbsp; Seems to emanate from the vintage ice box. &nbsp;I relax again realizing it's but a passing angry snowplow. &nbsp;There and gone with absolutely no regard for my questions.&nbsp;&nbsp; Invisibility juxtaposed to the necessity of modern life.</div>
<div></div>
<div></div>
<div></div>
<div>Nothing is taken and only footprints are left.&nbsp; Drove farther down the road to my destination and then back towards the curious house set on revisiting.</div>
<div></div>
<div></div>
<div></div>
</div>
<div>I don't know if I just got a little lost or took a wrong turn, but when I pass by what I thought was the house's location... there was no house at all.&nbsp;</div>
</div>
<div></div>
<div></div>
<div></div>
<div></div>
<p>&nbsp;</p>]]></content></entry></feed>